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Research Output 1996 2019

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2019
1 Citation (Scopus)

Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy

Janice Sánchez, B., Tremblay, A. M. K., Leduc-Gaudet, J. P., Hall, D. T., Kovacs, E., Ma, J. F., Mubaid, S., Hallauer, P. L., Phillips, B. L., Vest, K. E., Corbett, A. H., Kontoyiannis, D. L., Hussain, S. N. A., Hastings, K. E. M., Di Marco, S. & Gallouzi, I., 13 Sep 2019, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Muscle Neoplasms
atrophy
skeletal muscle
Muscular Atrophy
endurance

HuR counteracts miR-330 to promote STAT3 translation during inflammation-induced muscle wasting

Mubaid, S., Ma, J. F., Omer, A., Ashour, K., Lian, X. J., Sanchez, B. J., Robinson, S., Cammas, A., Dormoy-Raclet, V., Marco, S. D., Chittur, S. V., Tenenbaum, S. A. & Gallouzi, I., 27 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35

Research output: Contribution to journalArticle

Open Access
STAT3 Transcription Factor
MicroRNAs
Inflammation
Muscles
Messenger RNA
2018
1 Citation (Scopus)

EIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways

Cramer, Z., Sadek, J., Vazquez, G. G., Di Marco, S., Pause, A., Pelletier, J. & Gallouzi, I., 1 Dec 2018, In : Scientific Reports. 8, 1, 8414.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Nitric Oxide Synthase Type II
Eukaryotic Initiation Factor-4A
Cytokines
Muscles
4 Citations (Scopus)

Post-transcriptional regulation of Pabpn1 by the RNA binding protein HuR

Phillips, B. L., Banerjee, A., Sanchez, B. J., Marco, S. D., Gallouzi, I., Pavlath, G. K. & Corbett, A. H., 1 Jan 2018, In : Nucleic Acids Research. 46, 15, p. 7643-7661 19 p.

Research output: Contribution to journalArticle

Oculopharyngeal Muscular Dystrophy
RNA-Binding Proteins
Muscles
Alanine
Gene Expression
10 Citations (Scopus)

The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting

Hall, D. T., Griss, T., Ma, J. F., Sanchez, B. J., Sadek, J., Tremblay, A. M. K., Mubaid, S., Omer, A., Ford, R. J., Bedard, N., Pause, A., Wing, S. S., Di Marco, S., Steinberg, G. R., Jones, R. G. & Gallouzi, I., 1 Jan 2018, (Accepted/In press) In : EMBO Molecular Medicine.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Metformin
Inflammation
Muscles
A 769662
2017
18 Citations (Scopus)

STAT3 promotes IFNγ/TNFα-induced muscle wasting in an NF-κB-dependent and IL-6-independent manner

Ma, J. F., Sanchez, B. J., Hall, D. T., Tremblay, A. M. K., Di Marco, S. & Gallouzi, I., 2017, (Accepted/In press) In : EMBO Molecular Medicine.

Research output: Contribution to journalArticle

Interleukin-6
Muscles
Janus Kinases
Cachexia
Muscular Atrophy
2015
36 Citations (Scopus)

EEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection

Valiente-Echeverría, F., Melnychuk, L., Vyboh, K., Ajamian, L., Gallouzi, I., Bernard, N. & Mouland, A. J., 2015, In : Nature Communications. 5, 4819.

Research output: Contribution to journalArticle

ras GTPase-Activating Proteins
Peptide Elongation Factor 2
human immunodeficiency virus
src Homology Domains
infectious diseases
2014
28 Citations (Scopus)

Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation

Cammas, A., Sanchez, B. J., Lian, X. J., Dormoy-Raclet, V., Van Der Giessen, K., De Silanes, I. L., Ma, J., Wilusz, C., Richardson, J., Gorospe, M., Millevoi, S., Giovarelli, M., Gherzi, R., Di Marco, S. & Gallouzi, I., 27 Jun 2014, In : Nature Communications. 5, 4190.

Research output: Contribution to journalArticle

muscle fibers
muscle cells
destabilization
Muscle Development
Muscle
6 Citations (Scopus)

Regulation of eukaryotic initiation factor 4AII by MyoD during murine myogenic cell differentiation

Galicia-Vázquez, G., Di Marco, S., Lian, X. J., Ma, J. F., Gallouzi, I. & Pelletier, J., 23 Jan 2014, In : PLoS One. 9, 1, e87237.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
cell differentiation
myocytes
Muscle Cells
translation (genetics)
2013
10 Citations (Scopus)

A DIStinctively novel exoribonuclease that really likes U

Gallouzi, I. & Wilusz, J., 3 Jul 2013, In : EMBO Journal. 32, 13, p. 1799-1801 3 p.

Research output: Contribution to journalArticle

Exoribonucleases
MicroRNAs
RNA
Degradation
Substrates
30 Citations (Scopus)

Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis

Von Roretz, C., Jin Lian, X., MacRi, A. M., Punjani, N., Clair, E., Drouin, O., Dormoy-Raclet, V., Ma, J. F. & Gallouzi, I. E., Jan 2013, In : Cell Death and Differentiation. 20, 1, p. 154-168 15 p.

Research output: Contribution to journalArticle

Caspases
Caspase 9
Apoptosis
Messenger RNA
RNA-Binding Proteins
16 Citations (Scopus)

Aryl Hydrocarbon Receptor-Dependent Retention of Nuclear HuR Suppresses Cigarette Smoke-Induced Cyclooxygenase-2 Expression Independent of DNA-Binding

Zago, M., Sheridan, J. A., Nair, P., Rico de Souza, A., Gallouzi, I., Rousseau, S., Di Marco, S., Hamid, Q., Eidelman, D. H. & Baglole, C. J., 27 Sep 2013, In : PLoS One. 8, 9, e74953.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
cigarettes
prostaglandin synthase
Cyclooxygenase 2
smoke
39 Citations (Scopus)

HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA

Dormoy-Raclet, V., Cammas, A., Celona, B., Lian, X. J., Van Der Giessen, K., Zivojnovic, M., Brunelli, S., Riuzzi, F., Sorci, G., Wilhelm, B. T., Marco, S. D., Donato, R., Bianchi, M. E. & Gallouzi, I., 2013, In : Nature Communications. 4, 2388.

Research output: Contribution to journalArticle

Muscle Development
Myoblasts
Muscle
boxes
Binding Sites
7 Citations (Scopus)

Post-Transcriptional Regulation of Connexin43 in H-Ras-Transformed Cells

Kandouz, M., Zhao, J., Bier, A., Di Marco, S., Oviedo-Landaverde, I., Gallouzi, I. & Batist, G., 11 Mar 2013, In : PLoS One. 8, 3, e58500.

Research output: Contribution to journalArticle

Connexin 43
cells
Untranslated Regions
Genes
src Genes
2012
33 Citations (Scopus)
Poly Adenosine Diphosphate Ribose
Methylnitronitrosoguanidine
Alkylation
Proteomics
DNA
25 Citations (Scopus)

Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival

Robert, F., Mills, J. R., Agenor, A., Wang, D., DiMarco, S., Cencic, R., Tremblay, M. L., Gallouzi, I., Hekimi, S., Wing, S. S. & Pelletier, J., 1 Feb 2012, In : Cancer Research. 72, 3, p. 747-756 10 p.

Research output: Contribution to journalArticle

Cachexia
Anorexia
Protein Transport
Cytokines
Interleukin-10
39 Citations (Scopus)

The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice

Di Marco, S., Cammas, A., Lian, X. J., Kovacs, E. N., Ma, J. F., Hall, D. T., Mazroui, R., Richardson, J., Pelletier, J. & Gallouzi, I., 2012, In : Nature Communications. 3, 896.

Research output: Contribution to journalArticle

Cachexia
Nitric Oxide Synthase Type II
ribonucleic acids
muscles
inhibitors
2011
24 Citations (Scopus)

Down-regulation of cytokine-induced interleukin-8 requires inhibition of p38 Mitogen-activated Protein Kinase (MAPK) via MAPK phosphatase 1-dependent and -independent mechanisms

Dauletbaev, N., Eklove, D., Mawji, N., Iskandar, M., Di Marco, S., Gallouzi, I. & Lands, L. C., 6 May 2011, In : Journal of Biological Chemistry. 286, 18, p. 15998-16007 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Phosphatases
Dual Specificity Phosphatase 1
p38 Mitogen-Activated Protein Kinases
Interleukin-8
Down-Regulation
45 Citations (Scopus)

Inducible nitric oxide synthase (iNOS) in muscle wasting syndrome, sarcopenia, and cachexia

Hall, D. T., Ma, J. F., Marco, S. D. & Gallouzi, I., Aug 2011, In : Aging. 3, 8, p. 702-715 14 p.

Research output: Contribution to journalArticle

Sarcopenia
Wasting Syndrome
Cachexia
Nitric Oxide Synthase Type II
Muscles
12 Citations (Scopus)

Transportin 2 regulates apoptosis through the RNA-binding protein HuR

Von Roretz, C., Macri, A. M. & Gallouzi, I., 22 Jul 2011, In : Journal of Biological Chemistry. 286, 29, p. 25983-25991 9 p.

Research output: Contribution to journalArticle

Karyopherins
RNA-Binding Proteins
Cell death
Apoptosis
Cell Death
2010
23 Citations (Scopus)

Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation

Gherzi, R., Trabucchi, M., Ponassi, M., Gallouzi, I., Rosenfeld, M. G. & Briata, P., Jun 2010, In : Cell Death and Differentiation. 17, 6, p. 975-983 9 p.

Research output: Contribution to journalArticle

RNA Stability
Muscle Cells
Cell Differentiation
Phosphorylation
Messenger RNA
15 Citations (Scopus)

FasL expression in activated T lymphocytes involves HuR-mediated stabilization

Drury, G. L., Di Marco, S., Dormoy-Raclet, V., Desbarats, J. & Gallouzi, I., 8 Oct 2010, In : Journal of Biological Chemistry. 285, 41, p. 31130-31138 9 p.

Research output: Contribution to journalArticle

Fas Ligand Protein
T-cells
Stabilization
T-Lymphocytes
3' Untranslated Regions
29 Citations (Scopus)

Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR)

Von Roretz, C. & Gallouzi, I., 28 May 2010, In : Journal of Biological Chemistry. 285, 22, p. 16806-16813 8 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Caspase 8
Protein Kinases
RNA
Antigens
28 Citations (Scopus)

The cleavage of HuR interferes with its transportin-2-mediated nuclear import and promotes muscle fiber formation

Beauchamp, P., Nassif, C., Hillock, S., Van Der Giessen, K., Von Roretz, C., Jasmin, B. J. & Gallouzi, I., Oct 2010, In : Cell Death and Differentiation. 17, 10, p. 1588-1599 12 p.

Research output: Contribution to journalArticle

Karyopherins
Cell Nucleus Active Transport
Antigens
Muscles
Muscle Development
2009
28 Citations (Scopus)

2′,3′-cyclic nucleotide 3′-phosphodiesterase: A novel RNA-binding protein that inhibits protein synthesis

Gravel, M., Robert, F., Kottis, V., Gallouzi, I., Pelletier, J. & Braun, P. E., 2009, In : Journal of Neuroscience Research. 87, 5, p. 1069-1079 11 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Cyclic Nucleotides
Phosphoric Diester Hydrolases
Proteins
Oligodendroglia
12 Citations (Scopus)

Could stress granules be involved in age-related diseases?

Gallouzi, I., Sep 2009, In : Aging. 1, 9, p. 753-757 5 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Cyclin-Dependent Kinase Inhibitor p21
Cytoplasmic Granules
Biological Models
HSP70 Heat-Shock Proteins
26 Citations (Scopus)
Oxidative stress
Oxidative Stress
Cyclin-Dependent Kinase Inhibitor p21
Cell Aging
Proteins
36 Citations (Scopus)

The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites

Rivas-Aravena, A., Ramdohr, P., Vallejos, M., Valiente-Echeverría, F., Dormoy-Raclet, V., Rodríguez, F., Pino, K., Holzmann, C., Huidobro-Toro, J. P., Gallouzi, I. & López-Lastra, M., 30 Sep 2009, In : Virology. 392, 2, p. 178-185 8 p.

Research output: Contribution to journalArticle

HIV-1
ELAV Proteins
RNA-Binding Proteins
Reticulocytes
Xenopus laevis
2008
82 Citations (Scopus)

Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis

Mazroui, R., Di Marco, S., Clair, E., Von Roretz, C., Tenenbaum, S. A., Keene, J. D., Saleh, M. & Gallouzi, I., 14 Jan 2008, In : Journal of Cell Biology. 180, 1, p. 113-127 15 p.

Research output: Contribution to journalArticle

Caspases
Cytoplasm
Apoptosis
Aspartic Acid
Apoptosomes
2007
125 Citations (Scopus)

Inhibition of the ubiquitin-proteasome system induces stress granule formation

Mazroui, R., Di Marco, S., Kaufman, R. J. & Gallouzi, I., Jul 2007, In : Molecular Biology of the Cell. 18, 7, p. 2603-2618 16 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
AU Rich Elements
RNA Stability
Phosphorylation
33 Citations (Scopus)

Involvement of transportin 2-mediated HuR import in muscle cell differentiation

Van Der Giessen, K. & Gallouzi, I., Jul 2007, In : Molecular Biology of the Cell. 18, 7, p. 2619-2629 11 p.

Research output: Contribution to journalArticle

Karyopherins
Muscle Cells
Cell Differentiation
Muscles
Myogenin
20 Citations (Scopus)

Solution structure of YaeO, a rho-specific inhibitor of transcription termination

Gutiérrez, P., Kozlov, G., Gabrielli, L., Elias, D., Osborne, M. J., Gallouzi, I. & Gehring, K., 10 Aug 2007, In : Journal of Biological Chemistry. 282, 32, p. 23348-23353 6 p.

Research output: Contribution to journalArticle

Transcription
Bacterial Gene Expression Regulation
Nucleic Acids
Site-Directed Mutagenesis
Nuclear magnetic resonance
77 Citations (Scopus)

The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the β-actin mRNA in a U-rich-element-dependent manner

Dormoy-Raclet, V., Ménard, I., Clair, E., Kurban, G., Mazroui, R., Di Marco, S., Von Roretz, C., Pause, A. & Gallouzi, I., Aug 2007, In : Molecular and Cellular Biology. 27, 15, p. 5365-5380 16 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Cell Movement
Actins
Messenger RNA
HeLa Cells
2006
207 Citations (Scopus)

Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2α phosphorylation

Mazroui, R., Sukarieh, R., Bordeleau, M. E., Kaufman, R. J., Northcote, P., Tanaka, J., Gallouzi, I. & Pelletier, J., Oct 2006, In : Molecular Biology of the Cell. 17, 10, p. 4212-4219 8 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Ribosomes
Phosphorylation
RNA Helicases
Peptide Initiation Factors
2005
98 Citations (Scopus)

NF-κB-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release

Di Marco, S., Mazroui, R., Dallaire, P., Chittur, S., Tenenbaum, S. A., Radzioch, D., Marette, A. & Gallouzi, I., Aug 2005, In : Molecular and Cellular Biology. 25, 15, p. 6533-6545 13 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Nitric Oxide
Cytokines
Muscles
Messenger RNA
26 Citations (Scopus)

RNA-binding protein HuR is required for stabilization of SLC11A1 mRNA and SLC11A1 protein expression

Xu, Y. Z., Di Marco, S., Gallouzi, I., Rola-Pleszczynski, M. & Radzioch, D., Sep 2005, In : Molecular and Cellular Biology. 25, 18, p. 8139-8149 11 p.

Research output: Contribution to journalArticle

AU Rich Elements
RNA-Binding Proteins
HL-60 Cells
Messenger RNA
Gene Expression Regulation
2004
30 Citations (Scopus)

Nuclear localization of the adenovirus E4orf4 protein is mediated through an arginine-rich motif and correlates with cell death

Miron, M. J., Gallouzi, I., Lavoie, J. N. & Branton, P. E., 30 Sep 2004, In : Oncogene. 23, 45, p. 7458-7468 11 p.

Research output: Contribution to journalArticle

Arginine
Cell Death
Cell Nucleolus
Protein Phosphatase 2
Alanine
2003
92 Citations (Scopus)

RNAi-mediated HuR Depletion Leads to the Inhibition of Muscle Cell Differentiation

Van Der Giessen, K., Di-Marco, S., Clair, E. & Gallouzi, I., 21 Nov 2003, In : Journal of Biological Chemistry. 278, 47, p. 47119-47128 10 p.

Research output: Contribution to journalArticle

RNA Interference
Muscle Cells
Muscle
Cell Differentiation
AU Rich Elements
2001
221 Citations (Scopus)

Delineation of mRNA export pathways by the use of cell-permeable peptides

Gallouzi, I. & Steitz, J. A., 30 Nov 2001, In : Science. 294, 5548, p. 1895-1901 7 p.

Research output: Contribution to journalArticle

Messenger RNA
Peptides
Proteins
AU Rich Elements
Nuclear Export Signals
120 Citations (Scopus)

Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock

Gallouzi, I., Brennan, C. M. & Steitz, J. A., 2001, In : RNA. 7, 9, p. 1348-1361 14 p.

Research output: Contribution to journalArticle

Heat-Shock Response
Shock
Cell Nucleus Active Transport
Hot Temperature
Ligands
121 Citations (Scopus)

RasGAP-associated endoribonuclease G3BP: Selective RNA degradation and phosphorylation-dependent localization

Tourrière, H., Gallouzi, I., Chebli, K., Capony, J. P., Mouaikel, J., Van der Geer, P. & Tazi, J., 2001, In : Molecular and Cellular Biology. 21, 22, p. 7747-7760 14 p.

Research output: Contribution to journalArticle

Endoribonucleases
RNA Stability
Serine
Phosphorylation
Fibroblasts
2000
257 Citations (Scopus)

HuR binding to cytoplasmic mRNA is perturbed by heat shock

Gallouzi, I., Brennan, C. M., Stenberg, M. G., Swanson, M. S., Eversole, A., Maizels, N. & Steitz, J. A., 28 Mar 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 7, p. 3073-3078 6 p.

Research output: Contribution to journalArticle

AU Rich Elements
Shock
Hot Temperature
Messenger RNA
RNA-Binding Proteins
289 Citations (Scopus)

Protein ligands to HuR modulate its interaction with target mRNAs in vivo

Brennan, C. M., Gallouzi, I. & Steitz, J. A., 2 Oct 2000, In : Journal of Cell Biology. 151, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

AU Rich Elements
Ligands
Messenger RNA
Leucine
Proteins
1999
43 Citations (Scopus)

Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development

Labourier, E., Bourbon, H. M., Gallouzi, I., Fostier, M., Allemand, E. & Tazi, J., 15 Mar 1999, In : Genes and Development. 13, 6, p. 740-753 14 p.

Research output: Contribution to journalArticle

RNA Precursors
Drosophila
Proteins
U1 Small Nuclear Ribonucleoproteins
Small Nuclear Ribonucleoproteins
1998
143 Citations (Scopus)

A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: A potential link between signal transduction and RNA stability

Gallouzi, I., Parker, F., Chebli, K., Maurier, F., Labourier, E., Barlat, I., Capony, J. P., Tocque, B. & Tazi, J., Jul 1998, In : Molecular and Cellular Biology. 18, 7, p. 3956-3965 10 p.

Research output: Contribution to journalArticle

p120 GTPase Activating Protein
Endoribonucleases
src Homology Domains
RNA Stability
Staphylococcal Protein A
69 Citations (Scopus)

Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor

Labourier, E., Rossi, F., Gallouzi, I., Allemand, E., Divita, G. & Tazi, J., 15 Jun 1998, In : Nucleic Acids Research. 26, 12, p. 2955-2962 8 p.

Research output: Contribution to journalArticle

Serine
Arginine
Phosphotransferases
Phosphorylation
Adenosine Triphosphate
40 Citations (Scopus)

The C-terminal domain but not the tyrosine 723 of human DNA topoisomerase I active site contributes to kinase activity

Rossi, F., Labourier, E., Gallouzi, I., Derancourt, J., Allemand, E., Divita, G. & Tazi, J., 15 Jun 1998, In : Nucleic Acids Research. 26, 12, p. 2963-2970 8 p.

Research output: Contribution to journalArticle

Tyrosine
Catalytic Domain
Phosphotransferases
Adenosine Triphosphate
Proteolysis