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Research Output 1996 2019

  • 1972 Citations
  • 25 h-Index
  • 40 Article
  • 13 Review article
  • 1 Chapter
2019
6 Citations (Scopus)

Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues

Geng, L., Liao, B., Jin, L., Huang, Z., Triggle, C., Ding, H., Zhang, J., Huang, Y., Lin, Z. & Xu, A., 5 Mar 2019, In : Cell Reports. 26, 10, p. 2738-2752.e4

Research output: Contribution to journalArticle

Open Access
Adipose Tissue
Obesity
Tissue
Crosstalk
Transducers
2 Citations (Scopus)

Impact of currently used anti-diabetic drugs on myoendothelial communication

Ding, H., Ye, K. & Triggle, C., 1 Apr 2019, In : Current Opinion in Pharmacology. 45, p. 1-7 7 p.

Research output: Contribution to journalReview article

Metformin
Endothelium
Pharmaceutical Preparations
Vascular Diseases
Vasodilation
Sodium-Glucose Transport Proteins
Hyperglycemia
Type 2 Diabetes Mellitus
Blood Vessels
Oxidative Stress
1 Citation (Scopus)

Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug fenofibrate in VEGF-dependent angiosarcomas in vitro

Majeed, Y., Upadhyay, R., Alhousseiny, S., Taha, T., Musthak, A., Shaheen, Y., Jameel, M., Triggle, C. & Ding, H., 1 Dec 2019, In : Scientific reports. 9, 1, 6316.

Research output: Contribution to journalArticle

Open Access
Fenofibrate
Hypolipidemic Agents
Hemangiosarcoma
Peroxisome Proliferator-Activated Receptors
Vascular Endothelial Growth Factor A
1 Citation (Scopus)
Open Access
Thrombospondin 1
Metformin
Deoxyglucose
Up-Regulation
Endothelial Cells
2018
7 Citations (Scopus)

Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice

Lemmey, H. A. L., Ye, X., Ding, H., Triggle, C., Garland, C. J. & Dora, K. A., 1 Jan 2018, (Accepted/In press) In : Vascular Pharmacology.

Research output: Contribution to journalArticle

seryl-leucyl-isoleucyl-glycyl-arginyl-leucine
Vasodilation
Hyperglycemia
Endothelium
Mesenteric Arteries
11 Citations (Scopus)

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress

El-Daly, M., Pulakazhi Venu, V. K., Saifeddine, M., Mihara, K., Kang, S., Fedak, P. W. M., Alston, L. A., Hirota, S. A., Ding, H., Triggle, C. & Hollenberg, M. D., 1 Jan 2018, (Accepted/In press) In : Vascular Pharmacology.

Research output: Contribution to journalArticle

Sodium-Glucose Transporter 2
Symporters
Vasodilation
Hyperglycemia
Oxidative Stress
2017
32 Citations (Scopus)

Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium

Triggle, C. & Ding, H., 1 Jan 2017, In : Acta Physiologica. 219, 1, p. 138-151 14 p.

Research output: Contribution to journalReview article

Metformin
Vascular Endothelium
Hypoglycemic Agents
Pharmaceutical Preparations
Blood Vessels
16 Citations (Scopus)
Metformin
Endothelial cells
Cell death
Endoplasmic Reticulum Stress
Starvation
2016
43 Citations (Scopus)
Metformin
MicroRNAs
Hyperglycemia
Endothelial Cells
Glucose
2015
110 Citations (Scopus)

Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice

Lin, Z., Pan, X., Wu, F., Ye, D., Zhang, Y., Wang, Y., Jin, L., Lian, Q., Huang, Y., Ding, H., Triggle, C., Wang, K., Li, X. & Xu, A., 26 May 2015, In : Circulation. 131, 21, p. 1861-1871 11 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 2
Atherosclerosis
Liver
Apolipoproteins E
Hypercholesterolemia
54 Citations (Scopus)

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

Kinaan, M., Ding, H. & Triggle, C., 25 Jul 2015, In : Medical Principles and Practice. 24, 5, p. 401-415 15 p.

Research output: Contribution to journalReview article

Metformin
Endothelium
Pharmaceutical Preparations
AMP-Activated Protein Kinases
Therapeutics
23 Citations (Scopus)

Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions

Ghosh, S., Lakshmanan, A., Hwang, M. J., Kubba, H., Mushannen, A., Triggle, C. & Ding, H., 1 Dec 2015, In : Biochemical Pharmacology. 98, 3, p. 412-421 10 p.

Research output: Contribution to journalArticle

Metformin
Endothelial cells
Nitric Oxide Synthase Type III
Endothelial Cells
Tissue
14 Citations (Scopus)

MicroRNA signature and cardiovascular dysfunction

Arunachalam, G., Upadhyay, R., Ding, H. & Triggle, C., 1 May 2015, In : Journal of Cardiovascular Pharmacology. 65, 5, p. 419-429 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Cardiovascular Diseases
Biomarkers
Untranslated Regions
Small Untranslated RNA
6 Citations (Scopus)

Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population

Upadhyay, R., Robay, A., Fakhro, K. A. M. A., Khalil, A. A., Zirie, M., Jayyousi, A., El-Shafei, M., Kiss, S., D'Amico, D. J., Salit, J., Staudt, M. R., O'Beirne, S. L., Chen, X., Tuana, B., Crystal, R. & Ding, H., 15 Feb 2015, In : Journal of Translational Medicine. 13, 1, 61.

Research output: Contribution to journalArticle

Diabetic Retinopathy
Medical problems
Polymorphism
Genes
Population
2014
27 Citations (Scopus)

Cardiovascular impact of drugs used in the treatment of diabetes

Triggle, C. & Ding, H., 2014, In : Therapeutic Advances in Chronic Disease. 5, 6, p. 245-268 24 p.

Research output: Contribution to journalReview article

Cardiovascular Agents
Metformin
Pharmaceutical Preparations
Morbidity
Mortality
98 Citations (Scopus)

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

Liang, Q., Zhong, L., Zhang, J., Wang, Y., Bornstein, S. R., Triggle, C., Ding, H., Lam, K. S. L. & Xu, A., 1 Dec 2014, In : Diabetes. 63, 12, p. 4064-4075 12 p.

Research output: Contribution to journalArticle

Fasting
Homeostasis
Gluconeogenesis
Glucose
Liver
98 Citations (Scopus)

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

Arunachalam, G., Mathews Samuel, S., Marei, I., Ding, H. & Triggle, C., 1 Jan 2014, In : British Journal of Pharmacology. 171, 2, p. 523-535 13 p.

Research output: Contribution to journalArticle

Sirtuin 1
Metformin
Hyperglycemia
Apoptosis
Endothelial Cells
1 Citation (Scopus)

Peroxynitrite biology

Arunachalam, G., Mathews Samuel, S., Ding, H. & Triggle, C., 1 May 2014, Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, Vol. 9783642300189. p. 207-242 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxynitrous Acid
Free Radicals
Nitric Oxide
Reactive Nitrogen Species
Electrons
2012
60 Citations (Scopus)
Endoplasmic Reticulum Stress
Blood Vessels
Diabetes Mellitus
Diabetes Complications
Oxidative Stress
1 Citation (Scopus)
Apamin
Tubocurarine
Charybdotoxin
Mesenteric Arteries
Nitric Oxide Synthase Type III
134 Citations (Scopus)

The endothelium: Influencing vascular smooth muscle in many ways

Triggle, C., Mathews Samuel, S., Ravishankar, S., Marei, I., Arunachalam, G. & Ding, H., 12 Dec 2012, In : Canadian Journal of Physiology and Pharmacology. 90, 6, p. 713-718 6 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Endothelium
Epoprostenol
Blood Vessels
Nitric Oxide
2011
8 Citations (Scopus)
Tail
Adipose Tissue
Membrane Proteins
Abdominal Fat
Facilitative Glucose Transport Proteins
13 Citations (Scopus)

Perivascular adipose tissue-derived relaxing factors: Release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms

Li, Y., Mihara, K., Saifeddine, M., Krawetz, A., Lau, D., Li, H., Ding, H., Triggle, C. & Hollenberg, M. D., Dec 2011, In : British Journal of Pharmacology. 164, 8, p. 1990-2002 13 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Adipose Tissue
Peptides
seryl-leucyl-isoleucyl-glycyl-arginyl-leucine
4-Aminopyridine
22 Citations (Scopus)

The endothelium in compliance and resistance vessels

Triggle, C. & Ding, H., 1 Jan 2011, In : Frontiers in Bioscience - Scholar. 3 S, 2, p. 730-744 15 p.

Research output: Contribution to journalArticle

Compliance
Endothelium
Blood vessels
Blood
Microcirculation
2010
61 Citations (Scopus)
Nitric Oxide Synthase Type III
Hyperglycemia
Blood Vessels
Animal Models
74 Citations (Scopus)

Endothelial dysfunction in diabetes: Multiple targets for treatment

Ding, H. & Triggle, C., May 2010, In : Pflugers Archiv European Journal of Physiology. 459, 6, p. 977-994 18 p.

Research output: Contribution to journalReview article

Medical problems
Endothelium
Dyslipidemias
Vasodilation
Endothelium-Dependent Relaxing Factors
28 Citations (Scopus)
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Endothelial Cells
Calcium
Glucose
Adenosine Triphosphate
37 Citations (Scopus)
Oxidative stress
Endothelial cells
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Microvessels
2009
16 Citations (Scopus)

Endothelium-dependent vasodilation in myogenically active mouse skeletal muscle arterioles: Role of EDH and K+ channels

Potocnik, S., McSherry, I., Ding, H., Murphy, T., Kotecha, N., Dora, K., Yuill, K., Triggle, C. & Hill, M., 2009, In : Microcirculation. 16, 5, p. 377-390 14 p.

Research output: Contribution to journalArticle

Arterioles
Vasodilation
Smooth Muscle Myocytes
Endothelium
Apamin
2008
21 Citations (Scopus)

Effects of a Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature

Ellis, A., Cheng, Z. J., Li, Y., Jiang, Y. F., Yang, J., Pannirselvam, M., Ding, H., Hollenberg, M. D. & Triggle, C., 28 Dec 2008, In : European Journal of Pharmacology. 601, 1-3, p. 111-117 7 p.

Research output: Contribution to journalArticle

Endothelium
LDL Receptors
Glucose
Inbred C57BL Mouse
Vasodilation
2007
17 Citations (Scopus)

Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice

Ceroni, L., Ellis, A., Wiehler, W. B., Jiang, Y. F., Ding, H. & Triggle, C., 10 Apr 2007, In : European Journal of Pharmacology. 560, 2-3, p. 193-200 8 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Connexins
Mesenteric Arteries
Endothelium
Blood Vessels
57 Citations (Scopus)
Nitric Oxide Synthase Type III
NADPH Oxidase
Apolipoproteins E
Streptozocin
Oxidative Stress
25 Citations (Scopus)

Nitrosothiol stores in vascular tissue: Modulation by ultraviolet light, acetylcholine and ionomycin

Ng, E. S. M., Cheng, Z. J., Ellis, A., Ding, H., Jiang, Y., Li, Y., Hollenberg, M. D. & Triggle, C., 10 Apr 2007, In : European Journal of Pharmacology. 560, 2-3, p. 183-192 10 p.

Research output: Contribution to journalArticle

S-Nitrosoglutathione
Ionomycin
Ultraviolet Rays
Acetylcholine
Blood Vessels
67 Citations (Scopus)

Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells

Ding, H., Aljofan, M. & Triggle, C., Sep 2007, In : Journal of Cellular Physiology. 212, 3, p. 682-689 8 p.

Research output: Contribution to journalArticle

Oxidative stress
Nitric Oxide Synthase Type III
NADPH Oxidase
Endothelial cells
Microvessels
19 Citations (Scopus)
Prostaglandin H2 Receptors Thromboxane A2
Cytochrome P-450 Enzyme System
Blood Vessels
Endothelium
Acetylcholine
29 Citations (Scopus)

Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy

Wilson, A. M., Swan, J. D., Ding, H., Zhang, Y., Whitbourn, R. J., Gurry, J., Yii, M., Wilson, A. C., Hill, M., Triggle, C., Best, J. D. & Jenkins, A. J., Mar 2007, In : Atherosclerosis. 191, 1, p. 175-181 7 p.

Research output: Contribution to journalArticle

Tunica Intima
Protein C
C-Reactive Protein
Hypertrophy
Blood Vessels
2006
40 Citations (Scopus)

Pharmacological characteristics of endothelium-derived hyperpolarizing factor-mediated relaxation of small mesenteric arteries from db/db mice

Pannirselvam, M., Ding, H., Anderson, T. J. & Triggle, C., 3 Dec 2006, In : European Journal of Pharmacology. 551, 1-3, p. 98-107 10 p.

Research output: Contribution to journalArticle

Mesenteric Arteries
Endothelium
Bradykinin
Pharmacology
Acetylcholine
2005
81 Citations (Scopus)
Type 2 Diabetes Mellitus
Endothelium
Blood Vessels
Endothelial Cells
Endothelium-Dependent Relaxing Factors
74 Citations (Scopus)

Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse

Ding, H., Hashem, M., Wiehler, W. B., Lau, W., Martin, J., Reid, J. & Triggle, C., Dec 2005, In : British Journal of Pharmacology. 146, 8, p. 1110-1118 9 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Streptozocin
Mesenteric Arteries
Endothelium
Citric Acid
16 Citations (Scopus)

Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP

Ding, H., Howarth, A. G., Pannirselvam, M., Anderson, T. J., Severson, D. L., Wiehler, W. B., Triggle, C. & Tuana, B. S., Jul 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 289, 1 58-1

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Mesenteric Arteries
Tail
Membrane Proteins
Blood Vessels
20 Citations (Scopus)
Endothelium-Dependent Relaxing Factors
Type 2 Diabetes Mellitus
Endothelium
Nitric Oxide
Insulin Resistance
2004
31 Citations (Scopus)
Medical problems
Oxides
Type 2 Diabetes Mellitus
Endothelium
Blood Vessels
2003
3 Citations (Scopus)

Contribution of EDHF and the role of potassium channels in the regulation of vascular tone

Ding, H. & Triggle, C., 1 Jan 2003, In : Drug Development Research. 58, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Charybdotoxin
Potassium Channels
Endothelial cells
Epoprostenol
Endothelium
85 Citations (Scopus)

The Endothelium in Health and Disease - A Target for Therapeutic Intervention

Triggle, C., Hollenberg, M., Anderson, T. J., Ding, H., Jiang, Y., Ceroni, L., Wiehler, W. B., Ng, E. S. M., Ellis, A., Andrews, K., McGuire, J. J. & Pannirselvam, M., Dec 2003, In : Journal of Smooth Muscle Research. 39, 6, p. 249-267 19 p.

Research output: Contribution to journalReview article

Endothelium
Blood Vessels
Endothelium-Dependent Relaxing Factors
Health
Nitric Oxide
2002
35 Citations (Scopus)
Endothelium
Gap Junctions
Vascular Smooth Muscle
Smooth Muscle Myocytes
Endothelial Cells
2001
147 Citations (Scopus)

Endothelium-derived relaxing factors: A focus on endothelium-derived hyperpolarizing factor(s)

McGuire, J. J., Ding, H. & Triggle, C., 2001, In : Canadian Journal of Physiology and Pharmacology. 79, 6, p. 443-470 28 p.

Research output: Contribution to journalReview article

Endothelium-Dependent Relaxing Factors
Endothelium
Epoprostenol
Vasodilator Agents
Vascular Smooth Muscle
4 Citations (Scopus)

Relaxing blood vessels

Ding, H. & Triggle, C., 2001, In : Pharmaceutical News. 8, 6, p. 42-49 8 p.

Research output: Contribution to journalReview article

Endothelium
Blood Vessels
Potassium Channels
Epoprostenol
Nitric Oxide
2000
22 Citations (Scopus)
Endothelium-Dependent Relaxing Factors
Epoprostenol
Endothelium
Muscle
Vascular Smooth Muscle
62 Citations (Scopus)

Potassium- and acetylcholine-induced vasorelaxation in mice lacking endothelial nitric oxide synthase

Ding, H., Kubes, P. & Triggle, C., 2000, In : British Journal of Pharmacology. 129, 6, p. 1194-1200 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Vasodilation
Acetylcholine
Potassium
Mesenteric Arteries