• 2066 Citations
  • 26 h-Index
19962020

Research output per year

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Research Output

  • 2066 Citations
  • 26 h-Index
  • 40 Article
  • 13 Review article
  • 1 Chapter
  • 1 Short survey
2020

COVID-19: Learning from lessons to guide treatment and prevention interventions

Triggle, C. R., Bansal, D., Abd Farag, E. A. B., Ding, H. & Sultan, A. A., 1 Jan 2020, In : mSphere. 5, 3, e00317-20.

Research output: Contribution to journalShort survey

Open Access
2019

Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues

Geng, L., Liao, B., Jin, L., Huang, Z., Triggle, C. R., Ding, H., Zhang, J., Huang, Y., Lin, Z. & Xu, A., 5 Mar 2019, In : Cell Reports. 26, 10, p. 2738-2752.e4

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Impact of currently used anti-diabetic drugs on myoendothelial communication

Ding, H., Ye, K. & Triggle, C. R., Apr 2019, In : Current Opinion in Pharmacology. 45, p. 1-7 7 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
1 Citation (Scopus)

Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug fenofibrate in VEGF-dependent angiosarcomas in vitro

Majeed, Y., Upadhyay, R., Alhousseiny, S., Taha, T., Musthak, A., Shaheen, Y., Jameel, M., Triggle, C. & Ding, H., 1 Dec 2019, In : Scientific reports. 9, 1, 6316.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
1 Citation (Scopus)
2018

Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice

Lemmey, H. A. L., Ye, X., Ding, H., Triggle, C., Garland, C. J. & Dora, K. A., 1 Jan 2018, (Accepted/In press) In : Vascular Pharmacology.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress

El-Daly, M., Pulakazhi Venu, V. K., Saifeddine, M., Mihara, K., Kang, S., Fedak, P. W. M., Alston, L. A., Hirota, S. A., Ding, H., Triggle, C. & Hollenberg, M. D., 1 Jan 2018, (Accepted/In press) In : Vascular Pharmacology.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2017

Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium

Triggle, C. & Ding, H., 1 Jan 2017, In : Acta Physiologica. 219, 1, p. 138-151 14 p.

Research output: Contribution to journalReview article

37 Citations (Scopus)
17 Citations (Scopus)
2016
45 Citations (Scopus)
2015

Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice

Lin, Z., Pan, X., Wu, F., Ye, D., Zhang, Y., Wang, Y., Jin, L., Lian, Q., Huang, Y., Ding, H., Triggle, C., Wang, K., Li, X. & Xu, A., 26 May 2015, In : Circulation. 131, 21, p. 1861-1871 11 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

Kinaan, M., Ding, H. & Triggle, C. R., 25 Jul 2015, In : Medical Principles and Practice. 24, 5, p. 401-415 15 p.

Research output: Contribution to journalReview article

65 Citations (Scopus)

Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions

Ghosh, S., Lakshmanan, A., Hwang, M. J., Kubba, H., Mushannen, A., Triggle, C. & Ding, H., 1 Dec 2015, In : Biochemical Pharmacology. 98, 3, p. 412-421 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

MicroRNA signature and cardiovascular dysfunction

Arunachalam, G., Upadhyay, R., Ding, H. & Triggle, C. R., 1 May 2015, In : Journal of Cardiovascular Pharmacology. 65, 5, p. 419-429 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population

Upadhyay, R., Robay, A., Fakhro, K. A. M. A., Khalil, A. A., Zirie, M., Jayyousi, A., El-Shafei, M., Kiss, S., D'Amico, D. J., Salit, J., Staudt, M. R., O'Beirne, S. L., Chen, X., Tuana, B., Crystal, R. & Ding, H., 15 Feb 2015, In : Journal of Translational Medicine. 13, 1, 61.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2014

Cardiovascular impact of drugs used in the treatment of diabetes

Triggle, C. & Ding, H., 2014, In : Therapeutic Advances in Chronic Disease. 5, 6, p. 245-268 24 p.

Research output: Contribution to journalReview article

31 Citations (Scopus)

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

Liang, Q., Zhong, L., Zhang, J., Wang, Y., Bornstein, S. R., Triggle, C., Ding, H., Lam, K. S. L. & Xu, A., 1 Dec 2014, In : Diabetes. 63, 12, p. 4064-4075 12 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

Arunachalam, G., Samuel, S. M., Marei, I., Ding, H. & Triggle, C. R., 1 Jan 2014, In : British Journal of Pharmacology. 171, 2, p. 523-535 13 p.

Research output: Contribution to journalArticle

108 Citations (Scopus)

Peroxynitrite biology

Arunachalam, G., Samuel, S. M., Ding, H. & Triggle, C. R., 1 May 2014, Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, Vol. 9783642300189. p. 207-242 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
2012
64 Citations (Scopus)
1 Citation (Scopus)

The endothelium: Influencing vascular smooth muscle in many ways

Triggle, C. R., Samuel, S. M., Ravishankar, S., Marei, I., Arunachalam, G. & Ding, H., 12 Dec 2012, In : Canadian Journal of Physiology and Pharmacology. 90, 6, p. 713-718 6 p.

Research output: Contribution to journalArticle

139 Citations (Scopus)
2011
8 Citations (Scopus)

Perivascular adipose tissue-derived relaxing factors: Release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms

Li, Y., Mihara, K., Saifeddine, M., Krawetz, A., Lau, D., Li, H., Ding, H., Triggle, C. R. & Hollenberg, M. D., 1 Dec 2011, In : British Journal of Pharmacology. 164, 8, p. 1990-2002 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The endothelium in compliance and resistance vessels

Triggle, C. R. & Ding, H., 1 Jan 2011, In : Frontiers in Bioscience - Scholar. 3 S, 2, p. 730-744 15 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2010
61 Citations (Scopus)

Endothelial dysfunction in diabetes: Multiple targets for treatment

Ding, H. & Triggle, C. R., 1 May 2010, In : Pflugers Archiv European Journal of Physiology. 459, 6, p. 977-994 18 p.

Research output: Contribution to journalReview article

75 Citations (Scopus)

Glucose enhances expression of TRPC1 and calcium entry in endothelial cells

Bishara, N. B. & Ding, H., 1 Jan 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 1, p. H171-H178

Research output: Contribution to journalArticle

32 Citations (Scopus)
38 Citations (Scopus)
2009

Endothelium-dependent vasodilation in myogenically active mouse skeletal muscle arterioles: Role of EDH and K+ channels

Potocnik, S., McSherry, I., Ding, H., Murphy, T., Kotecha, N., Dora, K., Yuill, K., Triggle, C. & Hill, M., 12 Aug 2009, In : Microcirculation. 16, 5, p. 377-390 14 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2008

Effects of a Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature

Ellis, A., Cheng, Z. J., Li, Y., Jiang, Y. F., Yang, J., Pannirselvam, M., Ding, H., Hollenberg, M. D. & Triggle, C. R., 28 Dec 2008, In : European Journal of Pharmacology. 601, 1-3, p. 111-117 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2007

Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice

Ceroni, L., Ellis, A., Wiehler, W. B., Jiang, Y. F., Ding, H. & Triggle, C. R., 10 Apr 2007, In : European Journal of Pharmacology. 560, 2-3, p. 193-200 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
59 Citations (Scopus)

Nitrosothiol stores in vascular tissue: Modulation by ultraviolet light, acetylcholine and ionomycin

Ng, E. S. M., Cheng, Z. J., Ellis, A., Ding, H., Jiang, Y., Li, Y., Hollenberg, M. D. & Triggle, C. R., 10 Apr 2007, In : European Journal of Pharmacology. 560, 2-3, p. 183-192 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells

Ding, H., Aljofan, M. & Triggle, C. R., 1 Sep 2007, In : Journal of Cellular Physiology. 212, 3, p. 682-689 8 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
19 Citations (Scopus)

Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy

Wilson, A. M., Swan, J. D., Ding, H., Zhang, Y., Whitbourn, R. J., Gurry, J., Yii, M., Wilson, A. C., Hill, M., Triggle, C., Best, J. D. & Jenkins, A. J., 1 Mar 2007, In : Atherosclerosis. 191, 1, p. 175-181 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2006

Pharmacological characteristics of endothelium-derived hyperpolarizing factor-mediated relaxation of small mesenteric arteries from db/db mice

Pannirselvam, M., Ding, H., Anderson, T. J. & Triggle, C. R., 3 Dec 2006, In : European Journal of Pharmacology. 551, 1-3, p. 98-107 10 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2005
82 Citations (Scopus)

Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse

Ding, H., Hashem, M., Wiehler, W. B., Lau, W., Martin, J., Reid, J. & Triggle, C., 1 Dec 2005, In : British Journal of Pharmacology. 146, 8, p. 1110-1118 9 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP

Ding, H., Howarth, A. G., Pannirselvam, M., Anderson, T. J., Severson, D. L., Wiehler, W. B., Triggle, C. R. & Tuana, B. S., 1 Jul 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 289, 1 58-1, p. H206-H211

Research output: Contribution to journalArticle

16 Citations (Scopus)
20 Citations (Scopus)
2004
31 Citations (Scopus)
2003

Contribution of EDHF and the role of potassium channels in the regulation of vascular tone

Ding, H. & Triggle, C. R., 1 Jan 2003, In : Drug Development Research. 58, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The Endothelium in Health and Disease - A Target for Therapeutic Intervention

Triggle, C. R., Hollenberg, M., Anderson, T. J., Ding, H., Jiang, Y., Ceroni, L., Wiehler, W. B., Ng, E. S. M., Ellis, A., Andrews, K., McGuire, J. J. & Pannirselvam, M., 1 Dec 2003, In : Journal of Smooth Muscle Research. 39, 6, p. 249-267 19 p.

Research output: Contribution to journalReview article

85 Citations (Scopus)
2002
35 Citations (Scopus)
2001

Endothelium-derived relaxing factors: A focus on endothelium-derived hyperpolarizing factor(s)

McGuire, J. J., Ding, H. & Triggle, C. R., 1 Jan 2001, In : Canadian Journal of Physiology and Pharmacology. 79, 6, p. 443-470 28 p.

Research output: Contribution to journalReview article

148 Citations (Scopus)

Relaxing blood vessels

Ding, H. & Triggle, C. R., 1 Dec 2001, In : Pharmaceutical News. 8, 6, p. 42-49 8 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)
2000
22 Citations (Scopus)